Planning a Multi-Country South American Trip: Tips and Routes
This is a collaborative post.
South America is a vast continent filled with diverse cultures, stunning landscapes, and incredible experiences. Planning a multi-country trip can be both exciting and overwhelming. Whether you’re considering joining one of the many small group South America tours or organising your own adventure, these tips and suggested routes will help make your journey unforgettable.

Determine Your Must-See Destinations
Before diving into the details, make a list of the countries and specific sites you most want to visit. Some popular destinations include Machu Picchu in Peru, Iguazu Falls in Argentina and Brazil, the Amazon rainforest, and the vibrant cities of Rio de Janeiro and Buenos Aires. Prioritize your must-sees to help shape your itinerary.
Consider the Best Time to Travel
South America’s climate varies greatly depending on the region and time of year. Generally, the dry season (May to October) is the most popular time for travel, especially in the Andes. However, shoulder seasons can offer lower prices and fewer crowds. Research the weather patterns for your desired destinations to determine the best time for your trip.
Choose Your Route
With your priority destinations in mind, it’s time to plan your route. A classic South America itinerary might include:
- Peru: Lima, Cusco, and Machu Picchu
- Bolivia: La Paz, Salar de Uyuni (salt flats)
- Chile: San Pedro de Atacama, Santiago, Patagonia
- Argentina: Buenos Aires, Iguazu Falls, Mendoza
- Brazil: Rio de Janeiro, Iguazu Falls, Amazon rainforest
Decide on Transportation
South America offers various transportation options, including flights, buses, and trains. For longer distances, flying is often the most efficient choice. However, bus travel can be more cost-effective and provide stunning views of the landscape. Overnight buses can also save on accommodation costs. In some cases, trains offer a unique and scenic way to travel, such as the luxurious Belmond Andean Explorer in Peru.
Budget Wisely
South America can be an affordable destination, but costs vary widely depending on your travel style and the countries you visit. Accommodation, food, and activities tend to be more expensive in Brazil, Argentina, and Chile, while Peru and Bolivia are generally more budget-friendly. Don’t forget to factor in costs for visas, travel insurance, and vaccinations.
Embrace the Local Culture
One of the joys of travelling through South America is immersing yourself in the diverse cultures. Take the time to learn a few phrases in Spanish or Portuguese, try local cuisines, and participate in cultural experiences like tango lessons in Buenos Aires or visiting indigenous markets in Peru. Engaging with locals and embracing the unique aspects of each country will enrich your journey.
Be Flexible and Open-Minded
While having a plan is essential, be prepared for unexpected changes and opportunities. South America is known for its laid-back attitude, and schedules may not always run as precisely as you’re used to. Embrace the spontaneity and be open to new experiences that may arise during your trip.
Planning a multi-country South American adventure can be a thrilling and rewarding experience. By prioritising your must-see destinations, choosing the best time to travel, and being open to the local culture, you’ll create unforgettable memories. Whether you opt for the convenience of small group South America tours or embark on an independent journey, this incredible continent will leave you with a lasting impression of its beauty, diversity, and warmth.